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Created in 2004 to encompass Leo Burnett's various marketing services operations, Arc Worldwide has 1, 300 employees and 36 offices in 31 countries. In 2005 it continued to integrate businesses while increasing revenues and reaping rewards for creativity. It also appointed key members to its top management team, expanded its geographic reach and continued to enhance its client services. Among the high-profile appointments of 2005, Arc Worldwide President Marc Landsberg was given full leadership responsibilities for the company and named to oversee Arc North America. Andrew Edwards was promoted to President of Arc Europe, Middle East and Africa, and Mark Reardon was named President of Arc New York. The agency launched offices in Bangkok, Hong Kong, Jakarta, Kuala Lumpur, Melbourne, Singapore, Sydney and Taipei in 2005. Arc's New York office officially opened in June, after integrating several East Coast operations; the San Francisco office followed in July. The agency had significant new business wins in 2005. In North America, it notably won assignments from Miller Brewing Company, telecom operator Sprint, drinks group Diageo, appliance maker Whirlpool, the American Medical Association, and software group Oracle. In the UK, it won contracts with Baxters Food Group, Sunny Delight Beverages, Fiat Commercial Vehicles and Intercontinental Hotels Group, for instance, asthma. 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Proventil for menAirway spasm relaxants like proventil albuterol ; or sudafed may increase the risk of heart problems with nortriptyline and ranitidine. That "direct-to-consumer advertising is an excellent way to meet the growing demand for medical information, empowering consumers by educating them about health conditions and possible treatments." The education of patients--or physicians--is too important to be left to the pharmaceutical industry, with its pseudo educational campaigns designed, first and foremost. Therabel Pharma S.A. Therabel Group ; Therabel Pharma S.A. Therabel Group ; Teva Pharmaceutical Industries Teva Pharmaceutical Industries Teva Pharmaceutical Industries Teva Pharmaceutical Industries Teva Pharmaceutical Industries Teva Pharmaceutical Industries Farmapol Sp. z o.o. Zaklad Chemiczno-Farmaceutyczny ICN Polfa Rzeszw S.A. Polpharma S.A. Starogardzkie Zaklady Farmaceutyczne Teva Pharmaceutical Industries Przedsiebiorstwo Farmaceutyczne JELFA S.A Ranbaxy Laboratoires Ltd. Leiras Oy Generics UK ; Limited Anpharm S.A. Przedsiebiorstwo Farmaceutyczne ratiopharm GmbH Bimeda Fort Dodge and relafen. Throughout the environment because of contamination from energy production, metallurgy and associated processes. Mercury Government and High volume chemical agency issued fish with total reported advisories have releases of 2, 421 kg in significantly Ontario in 2004. heightened the Exposure through air public profile of deposition, with risks associated sources including coalwith mercury fired power plants. exposure. Nonylphenol Nonylphenols NPEs are high-volume Ethoxylates ethoxylates chemicals and wide i.e. Bisphenol NPE ; are also spread in Canada. A ; known to survive Studies are revealing waste-treatment widespread exposure at processes. levels with total reported releases of nnonylphenols mixed isomers ; 72, 390 kg in Ontario in 2004. According to Canadian public health authorities, drinking water remains a negligible source of nonylphenolic compounds to humans. Largest pathway tin cans with plastic linings ; and plastic bottles. Organochloride High profile risk. Widespread exposure Pesticides While widespread to pesticides is bans exist on evidenced by recent these pesticides, studies revealing toxic their persistence body burdens at levels and biohigh enough to cause accumulative concern. The public nature continues health impacts of this to be a concern. remains unclear as does the way several pesticides can interact and exert synergistic effects on the body. Gioendothelioma represent different growth patterns or stages in the development of a single type of hemangioma. 438. Phlebosclerotic colitis coincident with carcinoma in adenoma - Kimura Y., Kashima K., Daa T. et al. [Dr. Y. Kimura, Department of Pathology, Oita Medical University, Hasama-machi, Oita 879-5593, Japan] - PATHOL. INT. 2003 53 10 ; summ in ENGL Phlebosclerosis of the colon is a rare disease characterized by a thickening of the wall of the colon with fibrosis, hyalinization and calcification to the affected veins. These symptoms result in a type of ischemic colitis known as phlebosclerotic colitis. A case of phlebosclerotic colitis coincident with carcinoma in adenoma is reported. A 74-year-old Japanese woman was admitted to hospital because of a mass in her right lower abdomen. Abdominal computed tomography examination revealed linear calcifications in the wall of the cecum and the ascending colon. Colonoscopy revealed dark purple mucosa with multiple ulcers in the cecum and the ascending colon. Biopsy specimens showed a marked hyalinous thickening of the wall of small blood vessels in the mucosa. Phlebosclerotic colitis was suspected because of negative results with amyloid stain. Alternative ileocolic angiography showed the serpentine of the peripheral nature blood vessels and pooling at the late venous phase. Microscopic examination of the surgically resected colon revealed mucosal and submucosal fibrosis, and a thickening of the venous wall with fibrosis, hyalinization and calcification from the mucosa to the serosa, which caused a marked luminal narrowing. A small polypoid lesion was also found in the affected region and was diagnosed histologically as carcinoma in adenoma. To our knowledge, this is the first reported case of phlebosclerotic colitis complicated by carcinoma. 439. Results of Repeat Sigmoidoscopy 3 Years after a Negative Examination - Schoen R.E., Pinsky P.F., Weissfeld J.L. et al. [Dr. R.E. Schoen, Div. of Gastroenterol. and Hepatol., C Wing, Presbyterian University Hospital, 200 Lothrop St, Pittsburgh, PA 15213-2582, United States] - J. AM. MED. ASSOC. 2003 290 1 ; - summ in ENGL Context: The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain. Objective: To examine the yield of adenomas and cancer in the distal colon found by repeat flexible sigmoidoscopy FSG ; 3 years after a negative examination. Design, Setting, and Participants: Participants were drawn from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial PLCO ; , a randomized, controlled community-based study of cancer screening. The mean SD ; age was 65.7 4.0 ; years at study entry 1993-1995 ; and 61.6% were men. Individuals underwent screening FSG at baseline and at 3 years as part of the protocol and were referred to their personal physicians for further evaluation of screen-detected abnormalities. Results from subsequent diagnostic evaluations were tracked in a standardized fashion. Of 11583 eligible for repeat screening FSG 3 years after an initial negative examination, 9317 80.4% ; returned. Main Outcome Measures: Polyp or mass detection in distal colon at year 3 repeat FSG; incidence of adenoma or cancer in distal colon at year 3 examination; determination of reason for detection increased depth of insertion or improved preparation at the year 3 examination or detection in a previously examined area ; . Results: A total of 1292 returning participants 13.9% ; had a polyp or mass detected by FSG 3 years after the initial examination. In the distal colon, 3.1% 292 9317 ; were found to have an adenoma or cancer. The incidence of advanced adenoma n 72 ; or cancer n 6 ; in the distal colon was 78 0.8% ; of 9317. Of individuals with advanced distal adenomas detected at the year 3 examination, 80.6% 58 72 ; had lesions found in a portion of the colon that had been adequately examined at the initial sigmoidoscopy. Conclusions: Repeat FSG 3 years after a negative examination will detect advanced adenomas and distal colon cancer. Although the overall percentage with detected abnormalities is modest, these data raise concern about the impact of a prolonged screening interval after a negative examination. 440. The usefulness of 99m Tc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis - Imai E., Kaminaga T., Kawasugi K. et al. [Dr. E. Imai, Department of Radiology Medicine, Teikyo University Section 48 vol 65.2 and remeron. 1. 2. 3. Admit to: Diagnosis: Bronchiolitis Condition: Vital signs: Call MD if: Activity: Nursing: Pulse oximeter, peak flow rate. Respiratory isolation. Diet: IV Fluids: Special Medications: -Oxygen, humidified 1-4 L min by NC or 40-60% by mask, keep sat 92%. Nebulized Beta 2 Agonists: -Albuterol Ventolin, Proventil ; 5 mg mL sln ; nebulized 0.2-0.5 mL in 2 mL 0.10-0.15 mg kg ; q1-4h prn. Treatment of Respiratory Syncytial Virus severe lung disease or underlying cardiopulmonary disease ; : -Ribavirin Virazole ; therapy should be considered in high risk children 2 yrs with bronchopulmonary dysplasia or with history of premature birth less than 35 weeks gestational age. Ribavirin is administered as a 6 vial, aerosolized by SPAG nebulizer over 18-20h qd x 3-5 days or 2 gm over 2 hrs q8h x 3-5 days. Prophylaxis Against Respiratory Syncytial Virus: -Recommended use in high risk children 2 yrs with BPD who required medical management within the past six months, or with history of premature birth less than or equal to 28 weeks gestational age who are less than one year of age at start of RSV season, or with history of premature birth 29-32 weeks gestational age who are less than six months of age at start of RSV season. -Palivizumab Synagis ; 15 mg kg IM once a month throughout RSV season usually October-March ; -RSV-IVIG RespiGam ; 750 mg kg IV once a month throughout RSV season usually from October to March ; . Influenza A: -Oseltamivir Tamiflu ; yr and 15 kg: 30 mg PO bid 15-23 kg: 45 mg PO bid 23 - 40 kg: 60 mg PO bid 40 kg: 75 mg PO bid 18 yr: 75 mg PO bid [cap: 75 mg; susp: 12 mg mL] Approved for treatment of uncomplicated influenza A or B when patient has been symptomatic no longer than 48 hrs. OR.
BY: Harry S. Davis Michael E. Swartz Matthew S. Wild1 Antitrust Pre-Merger Notification A. Introduction. The Hart-Scott-Rodino Antitrust Improvements Act "HSR" ; imposes legal obligations to report certain transactions to the antitrust regulators before buying certain levels of a company's stock. It is important for activist investors to understand the HSR filing thresholds and abide by them. Failure to comply with HSR even if the underlying transaction is not anticompetitive can subject the activist investor to a government investigation and significant fines. HSR and its regulatory scheme require anyone with a net worth that exceeds .3 million and plans to acquire more than .7 million of a company's stock to file a Notification and Report Form with the Federal Trade Commission "FTC" ; and United Department of Justice, Antitrust Division "Antitrust Division" ; and observe a 30-day waiting period before the investor acquires the stock. The most important implications of HSR for an activist investor are 1 ; the preacquisition notification requirement, 2 ; the 30-day waiting period, during which purchases of voting securities of the target may be limited, and 3 ; the filing fee, which is a minimum of , 000 and rises to 5, 000 for investments over 3.4 million and 0, 000 for investments over 7 million. Importantly, the fine for non-compliance is , 000 per day. 1. Filing Thresholds. An activist investor who after completion of the transaction, will hold voting securities of the target issuer valued in excess of .7 million is required to comply with HSR and its regulations. The HSR regulations determine whether this threshold is met by aggregating the value of the voting securities held by the acquiring person prior to the acquisition and the voting securities to be acquired. Voting securities held prior to the acquisition are valued at the lowest closing bid price within the 45 calendar days prior to the transaction in question, rather than at their cost or current value. a ; HSR regulations require the acquiring person to indicate the value of the contemplated transaction based upon the voting securities currently held and contemplated for purchase ; . The Notification and Report Form establishes five thresholds -- whether the value of the transaction will exceed .7 million, 3.4 million, 7 million, 25% of the target's voting securities if their value Harry S. Davis and Michael E. Swartz are litigation partners with Schulte Roth & Zabel LLP whose practices focus on complex litigation and antitrust counseling. Matthew S. Wild is a litigation associate with Schulte Roth & Zabel LLP whose practice focuses on antitrust counseling and litigation. Section 1 of this Outline relies in part on "Antitrust Report Under the Hart-Scott-Rodino Act, published in SRZ Activist Investing Developments Spring 2006 ; and written by Mark K. Marks. Ms. Marks is special counsel to Schulte Roth & Zabel LLP and specializes in Hart-Scott-Rodino Act reporting. Proventil what isThese drugs are quick working and the effects are of short duration, for instance, combivent.
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